Mediators of Inflammation / 2014 / Article / Tab 4

Review Article

Interferons and Interferon Regulatory Factors in Malaria

Table 4

Diverse roles of different IRFs in malaria infection.

Host
/model
InfectionFunctionsRef.

IRF-1HumanP. falciparum Controls parasitemia[123]
Not involved in development of severe malaria[124]
MicePy nigeriensis N67 iRBCsPlays a role in IFN-I signaling[85]
PbA iRBCsInvolved in ECM development
Controls parasitemia
[69]
Involved in ECM development
Promotes parasitemia
[125]
Regulates production of IFN- and IL12p4
Controls CD8+ T cells numbers
[72]
Plays a role in ECM development[70, 95]
Ex vivo AT-rich oligonucleotidesNo effect on IFN- production by splenocytes[61]

IRF-3MiceP. yoelii sporozoiteMediates IFN-I-induced innate response during liver-stage infection[126]
P. chabaudi iRBCsMediates splenic IFN- , but not IFN- , transcription in red pulp macrophages[90]
Not involved in IFN-I production[110]

IRF-5Ex vivo AT-rich oligonucleotidesNot involved in IFN- production by splenocytes[61]

IRF-7MicePy nigeriensis N67 iRBCsPlays a role in IFN-I signaling[85]
PbA iRBCsPlays a role in ECM development[70, 71]
P.chabaudi iRBCsMediates splenic IFN-I transcription in red pulp macrophages [90]
Involved in IFN-I production[110]

IRF-3 and IRF-7MicePbA sporozoiteMediate IFN-I response in liver-stage infection
Control parasite load in the liver
[92]
PbA iRBCsInvolved in ECM development [61]
Ex vivo AT-rich oligonucleotidesMediate IFN- production by splenocytes
Pf iRBCsMediate IFN- production by macrophages

IRF-8 Mice PbA iRBCsPlays a role in ECM development [95]
Regulates production of proinflammatory cytokines
Mediates IFN-I production
Controls antigen processing and presentation and chemotaxis
[72]

IRF-9MicePy nigeriensis N67 iRBCsPlays a role in IFN-I signaling[85]
PbA iRBCsPlays a role in ECM development[72]