CD8+ T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?
Proposed model for activation of specific CD8+ lymphocytes during infection of T. cruzi in naive or AdASP-2 immunized mice. Specific CD8+ T cells activated with APC containing T. cruzi antigen induce higher levels of expression of CD95 and low viability of T cells. This poor viability leads to a suboptimal response and host pathology (death or chronic infection). In contrast, the contact of APC pulsed with recombinant ADASP-2 activates specific CD8+ T cells with low expression of CD95. In the second contact with APC pulsed with T. cruzi antigen, specific CD8+ T cells with phenotype develop a strong immune response driving parasite elimination and promoting cure of the infection.