CD8⁺ T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?

Table 2

Summary of the different antigen delivery systems used for the induction of CD8⁺ T cells against experimental T. cruzi infection.

Delivery system	Adjuvant	T. cruzi antigen/gene	Reference
Rec. protein	Freund’s adjuvant	TS	[40]
Rec. Protein	CpG ODN	TS	[41]
Rec. Protein	CpG ODN	Cruzipain	[42]
Rec. protein	Alum/CpG ODN	ASP-2	[38]
			[43]
Plasmid DNA	None	TSA-1	[44]
			[45]
			[46]
Plasmid DNA	IL-12	TSA	[47]
			[48]
Plasmid DNA	None	TS	[49]
			[50]
			[41]
Plasmid DNA	None	ASP-1	[51]
Plasmid DNA	None	ASP-2	[51]
			[52]
			[53]
			[54]
			[55]
Plasmid DNA	None	ASP-3	[56]
Plasmid DNA	None	ASP-4	[56]
Plasmid DNA	None	CRP	[57]
Plasmid DNA	None	KMP11	[58]
Plasmid DNA	None	Tc24	[45]
Plasmid DNA	IL-12/GM-CSF	TcG1	[59]
Plasmid DNA	IL-12/GM-CSF	TcG2	[59]
Plasmid DNA	IL-12/GM-CSF	TcG4	[59]
Rec. adenovirus	None	TS	[60]
		ASP-2	[60]
Rec. Salmonella	None	Cruzipain	[61]
Sendai virus	None	ASP-2	[62]
Yellow fever 17D	None	ASP-2	[63]
Rec. adenovirus + Rec. MVA	None	TSA	[64]
Plasmid DNA + Rec. Adenovirus	None	ASP-2	[28]
Plasmid DNA + Rec. Adenovirus	None	ASP-2	[65]
Rec. influenza + Rec. Adenovirus	None	ASP-2	[65, 66]
Plasmid + Rec. MVA	IL-12/GM-CSF	TcG2/TcG4	[67]
Plasmid + Rec. protein	IL-12/GM-CSF	TcG1/TcG2/TcG4	[68]