Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases
Expression of ROR γt and Foxp3 mRNA in CTD and CTD-aPAH patients and healthy controls. mRNA expression in PBMCs from studied subjects was measured by real-time quantitative polymerase chain reaction. The result was normalized relative to GAPDH. (a) The expression of ROR γt mRNA in CTD, CTD-aPAH, and control group. (b) The expression of Foxp3 mRNA in CTD, CTD-aPAH, and control group. (c) The expression of RORγt and Foxp3 mRNA in subgroups of mild to moderate CTD-aPAH and severe CTD-aPAH. Compared with control group, ; Compared with CTD group, .