In Vitro Endothelial Cell Proliferation Assay Reveals Distinct Levels of Proangiogenic Cytokines Characterizing Sera of Healthy Subjects and of Patients with Heart Failure
Table 2
Circulating levels of cytokines/chemokines in sera from HF patients stratified based on the endothelial cell proliferation index (“high CI” versus “low CI”).
Cytokines/chemokines
HF patients
“High CI”
“Low CI”
EGF
126.5 ()
104 ()
n.s
EOTAXIN
141.5 ()
117 ()
n.s
G-CSF
25.4 ()
23.1 ()
n.s
GM-CSF
5.5 ()
3.7 ()
n.s
IFN-2
6.7 ()
2.6 ()
n.s
IFN-
3.3 ()
1.5 ()
<0.05
IL-10
0.4 ()
0.2 ()
n.s
IL-12p40
<OOR
<OOR
/
IL-12p70
2.1 ()
0.2 ()
n.s
IL-13
<OOR
<OOR
/
IL-15
1.5 ()
0.3 ()
n.s
IL-17
<OOR
<OOR
/
IL1ra
11.3 ()
6.5 ()
n.s
IL-1
1 ()
1.5 ()
n.s
IL-1
<OOR
<OOR
/
IL-2
<OOR
<OOR
/
IL-3
<OOR
<OOR
/
IL-4
<OOR
<OOR
/
IL-5
<OOR
<OOR
/
IL-6
5.7 ()
1.6 ()
n.s
IL-7
4.7 ()
2.9 ()
<0.05
IL-8
34.1 ()
16.3 ()
<0.06
IP-10
293 ()
342 ()
n.s
MCP-1
663.5 ()
471 ()
n.s
MIP-1
4.5 ()
3.8 ()
<0.06
MIP-1β
37.3 ()
36.5 ()
n.s
TNF-α
10.9 ()
8.7 ()
n.s
TNF-β
<OOR
<OOR
/
VEGF
290 ()
85.6 ()
<0.05
CI: cell index. Values are expressed as pg/mL and reported as median (mean ± SD). OOR<: out of (below) detection range; n.s: nonstatistically significant; : statistically significant; : close to statistically significant.
