Amyloidosis, Inflammation, and Oxidative Stress in the Heart of an Alkaptonuric Patient
Figure 1
(a) Ochronotic pigmentation on the surface of the valve was visible. A thickening of the central areas of the cusps with nodule-like structures is visible (arrow). (b) Light microscopy (hematoxylin and eosin staining) examinations of AKU aortic valve with intense inflammatory cell infiltrate that includes large cells macroscopically corresponding to macrophages (arrows). Magnification 20x. (c) Melanin-like ochronotic pigment was particularly detected by Fontana-Masson staining. Magnification 10x.
