Novel Insights into miRNA in Lung and Heart Inflammatory Diseases

<table>Role of miRNAs in mechanism of fibrosis. The downregulation of miR-200 and -192 (inhibits epithelial-mesenchymal transition, EMT) and miR-29 (prevents the deposition of extracellular matrix, ECM) promotes fibrosis. Further, miR-21 amplifies<i> TGF-<i>β</i></i> signaling and promotes myofibroblasts phenotype in fibrosis. This is characterized by increased cellular <svg height="13.95" id="M29" style="vertical-align:-0.12538pt" version="1.1" viewbox="0 0 53.525002 13.95" width="53.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> and expression of alpha-smooth muscle actin (<i>α</i>-SMA) and EDA-fibronectin.</table>

Mediators of Inflammation

Novel Insights into miRNA in Lung and Heart Inflammatory Diseases

Figure 2