|
| MicroRNA | SNP* risk variant (alleles) | Location | Putative role | References |
|
| Asthma | | | | |
| miR-146a | rs2910164*C (C/G) | Pre-miRNA region of miR-146a | Protection/lower risk of asthma | [12, 13] |
| miR-149 | rs2292832*T (C/T) | Pre-miRNA region of miR-149 | Associated with lower risk of asthma | [12] |
| miR-152 family (miR-148a, -148b, and -152) | rs1063320*G (C/G) | HLA-G -UTR (at + 3142 position) | Protective against asthma only in children of asthmatic mothers | [11, 15] |
| Chronic obstructive pulmonary disease (COPD) | | | | |
| miR-196a2 | rs11614913*C (C/T) | Pre-miRNA region of miR-196a2 | Target Hoxb8; decreased risk factor | [25] |
| miR-499 | rs3746444*G (A/G) | Pre-miRNA regions of hsa-miR-499 | Decreased risk factor | [25] |
| Cystic fibrosis (CF) | | | | |
| miR-433 and -509-3p | rs10234329 (A/C) | CFTR -UTR | Mild CFTR mutation and may have a role in pathogenesis of CF | [33] |
| Pulmonary tuberculosis (PTB) | | | | |
| miR-499 | rs3746444*C (T/C) | Pre-miRNA regions of hsa-miR-499 | Disease susceptibility varies among different populations | [25] |
| miR-146a | rs2910164*G (G/C) | Precursor miRNA sequence of miR-146a | Disease susceptibility varies among different populations; regulates cytokine signaling and TLR pathways | [25, 27] |
| Systemic lupus erythematosus (SLE) | | | | |
| miR-569 | rs1057233*T (T/C) | SPI1 -UTR | High susceptibility to SLE | [28] |
| miR-146a | rs57095329*G (G/A) | Promoter of miR-146a primary transcript | Associated with SLE | [29, 30, 34] |
| miR-146a | rs2431697*T (C/T) | Intergenic region between PTTG1 and miR-146a | Genetically associated with SLE in Europeans. | [31] |
| miR-3148 | rs3853839*G (G/C) | TLR7 -UTR | Increased risk for SLE | [32] |
| Congenital heart disease | | | | |
| miR-196a2 | rs11614913*C (C/T) | Pre-miRNA region of miR-196a2 | Increased risk | [24] |
| Hypertension (HT) | | | | |
| miR-155 | rs5186*C (A/C) | AGTR1 -UTR | Risk factor for HT and other CVDs | [35, 36] |
| miR-195 and -135 | rs9818870 (C/T) | MRAS -UTR | Risk factor for HT and other CVDs | [37] |
| miR-31 and -584 | rs7079 (C/A) | AGT -UTR | Risk factor for HT | [38] |
| Coronary heart disease | | | | |
| miR-149 | rs4846049*G (G/T) | MTHFR -UTR | Increased disease risk | [39] |
| Myocardial infarction | | | | |
| miR-149 precursor | rs71428439*G (A/G) | | Affects miR-149 maturation and regulates Puma protein in apoptosis | [40] |
| Dilated cardiomyopathy (DCM) | | | | |
| miR-196a2 | rs11614913*T (C/T) | Pre-miRNA region of miR-196a2 | Increased disease risk | [41] |
| miR-499 | rs3746444*G (A/G) | Pre-miRNA regions of hsa-miR-499 | Increased disease risk | [41] |
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