Novel Insights into miRNA in Lung and Heart Inflammatory Diseases

Table 2

Role of miRNAs in epigenetic regulation of lung inflammatory diseases and cardiac remodeling.

Disease and miRNA	Putative role in disease susceptibility	References
Idiopathic pulmonary fibrosis (IPF)
miR-17~92 cluster	Hypermethylation and increased DNMT-1 expression: ↓miR-17~92 in lung biopsies and lung fibroblasts from IPF patients	[71]
SLE
miR-21	Targets RASGRP1 and alters DNMT1 activity; DNA hypomethylation in disease state	[56]
miR-29b	Targets DNMT1; hypomethylation	[58]
miR-126	Inhibits DNMT1	[57]
miR-148a	Inhibits DNMT1	[56]
Myocardial infarction
miR-21	Acetylation regulates miR-21 promoter in myocardial infarction	[72]