Niacin Inhibits Vascular Inflammation via Downregulating Nuclear Transcription Factor-κB Signaling Pathway

Figure 5

Niacin decreased the secretion of TNF-α and IL-6 and inhibited NF-κB and notch1 expression in oxLDL-stimulated THP-1 macrophages. (a) and (b) show the relative levels of TNF-α and IL-6 secretion in the medium of THP-1 macrophages. The concentrations of IL-6 and TNF-α were determined by ELISA kit. (c) and (d) show the representative images of NF-κB p65 and notch1 protein expression in THP-1 macrophages by western blot. (e) and (f) show the IOD ratios of NF-κB p65 and notch1 expression, respectively. Data are presented as mean ± SD. ^##𝑃<0.01 versus blank group; ^∗𝑃<0.05; ^∗∗𝑃<0.01 versus oxLDL-treated group without niacin.