Niacin Inhibits Vascular Inflammation via Downregulating Nuclear Transcription Factor-κB Signaling Pathway

Table 1

Effect of niacin and simvastatin on plasma inflammatory markers (CRP, IL-6, and TNF-α) of guinea pig fed high fat diet.

Group	CRP (ng/L)	IL-6 (ng/L)	TNF-𝛼 (ng/L)
CD	3169.9±219.7	258.8±25.2	130.8±9.2
HFD	3211.3±153.8	265.8±24.2	143.0±15.7
HFD-N	3023.1±180.6	215.2±38.5^∗∗	117.9±17.9^∗∗
HFD-S	2955.7±257.8^∗	236.7±21.6^∗	114.4±19.3^∗∗

The contents of CRP, IL-6, and TNF-𝛼 in guinea pig plasma were measured by ELISA method after 8 weeks’ treatment. Data are presented as mean ± SD (𝑛=8). ^∗𝑃<0.05; ^∗∗𝑃<0.01 versus HFD group.