Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

Table 1

Syk family kinases and their characteristics.

Family	Domains	Expressing cells	Functions	References
Syk	Two SH; One kinase	Hematopoietic cells	Cell adhesion	[18, 36, 80–83, 85–90]
		B cells	Innate pathogen recognition
		Macrophages	Tissue damage recognition
		Mast cells	Inflammatory responses
		Neutrophils	Antibody-dependent cellular cytotoxicity
Syk-B	Two SH	Lymphocytes	Interference with Syk biological activities	[18, 20]
	One kinase	Breast tumor cells
ZAP70	Two SH	T cells	T-cell development and activation	[18, 119, 120]
	One kinase	Natural killer cells	Antibody-dependent cellular cytotoxicity