Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

Table 3

Summary of Syk inhibitors in clinical trials.

Name/structure	Activity	Indication	Phase	References
	Ki 30 nM; EC50 40–160 nM	Rheumatoid arthritis	II	[3, 95, 109]
	—	Rheumatoid arthritis	II	[3, 95, 109]
	Ki 96 nM; EC50 280 nM	Allergic rhinitis	II	[3, 112]
	—	Allergic asthma	I	[3, 95]