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Mediators of Inflammation
Volume 2014, Article ID 274048, 5 pages
Research Article

Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat

1Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam 6931435647, Iran
2Student Researches Committee, Ilam University of Medical Sciences, Ilam 6931435647, Iran
3Department of Physiology, Faculty of Veterinary, Ilam University, Ilam 6931435647, Iran
4Department of Animal Physiology, Faculty of Veterinary, University of Tehran, Tehran 1419963111, Iran
5Department of Epidemiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam 6931435647, Iran
6The researches Centre of Psychosocial Injuries, Ilam University of Medical Sciences, Ilam 6931435647, Iran

Received 14 June 2014; Revised 11 August 2014; Accepted 13 August 2014; Published 28 August 2014

Academic Editor: Vinod K. Mishra

Copyright © 2014 Yosouf Mohsenzadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study aimed to investigate any inflammatory effect of nicotine on rat embryo by exposing their mothers to different dosages of nicotine during pregnancy. During this experimental study, 32 pregnant healthy Wistar rats were divided into 4 equal groups, including a control and 3 nicotine exposure groups. Injections were performed subcutaneously starting at the first day of pregnancy until parturition. As the dosages of nicotine were increased, the weight gain by pregnant rats and the mean weight of their newborns were significantly reduced. Mean ± SD of hs-CRP was significantly higher among groups exposed to various dosages of nicotine (2, 4, and 6 mg/kg) compared to the control group () and its increasing rate was also dose dependent. Mean ± SD serum level of IL-6 and TNF- among all groups exposed to nicotine, except for 2 mg/kg nicotine injected group, was increased significantly (). Mean ± SD of serum level of TGF- and nitrite oxide among exposure groups showed significant differences compared to the control group only at the dosage of 6 mg/kg (). The current study showed that exposing pregnant rats to nicotine causes a dose dependent increase in the rate of all the studied inflammatory serum markers among their newborns.