HO-1 Induction by CO-RM2 Attenuates TNF-α-Induced Cytosolic Phospholipase A2 Expression via Inhibition of PKCα-Dependent NADPH Oxidase/ROS and NF-κB

<table>Effects of CORM-2 on the TNF-α-induced cPLA2 expression. TNF-α stimulated NF-κB activation through TNFR1/PKCα/IKKα/β, and p38 MAPK-, JNK-1/2-dependent NOX/ROS pathways resulting in cPLA2 expression in RASFs. The downregulation of TNF-α-induced cPLA2 expression by CORM-2 is mediated by the reduction in NF-κB transcriptional activity and decrease in generation of NOX/ROS.</table>

Mediators of Inflammation

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Figure 8

Figure 8: HO-1 Induction by CO-RM2 Attenuates TNF-α-Induced Cytosolic Phospholipase A2 Expression via Inhibition of PKCα-Dependent NADPH Oxidase/ROS and NF-κB

Figure 8 | HO-1 Induction by CO-RM2 Attenuates TNF-α-Induced Cytosolic Phospholipase A2 Expression via Inhibition of PKCα-Dependent NADPH Oxidase/ROS and NF-κB 