Mediators of Inflammation / 2014 / Article / Tab 1

Research Article

Relationship between Early Inflammatory Response and Clinical Evolution of the Severe Multiorgan Failure in Mechanical Circulatory Support-Treated Patients

Table 1

Clinical characteristics of patients and perioperative data.

All casesmax tSOFA score < 11max tSOFA
score ≥ 11
( )(Group A = 32)Outcome + (group B = 8)Outcome − (group C = 13)

Age, years54 (48–61)52 (45–58)53 (49–62)57 (52–66)0.052
Male gender, (%)49 (93)31 (97)7 (88)11 (85)0.313
INTERMACS profile, (%)0.610
 115 (28)8 (25)2 (25)5 (38)
 215 (28)10 (31)2 (25)3 (23)
 322 (42)14 (44)4 (50)4 (31)
 41 (2)1 (8)
Etiology, (%):0.318
 DCM30 (57)20 (63)5 (63)5 (39)
 ICM22 (41)12 (37)3 (37)7 (53)
 Myocarditis1 (2)1 (8)
MAP, mmHg75 (70–85)78 (72–85)75 (69–83)73 (68–83)0.499
LVEF, %21 (18–26)23 (18–26)26 (19–28)20 (16–21)0.045
LVEDV, mL260 (190–312)260 (190–330)239 (174–326)237 (161–292)0.466
RAP, mmHg6 (4–10)5 (3–8)8 (4–15)9 (4–16)0.163
PCWP, mmHg24 (18–30)24 (15–30)23 (10–33)24 (19–31)0.865
CI, L/min/m21.69 (1.36–2.00)1.70 (1.51–2.08)1.32 (1.07–1.47)*1.69 (1.45–1.83)0.023
Treatments, (%)
 ACEi + ATII34 (67)21 (68)5 (63)8 (67)0.961
 Beta-blocker31 (61)20 (65)6 (75)5 (42)0.259
 Statins13 (27)9 (30)2 (25)2 (18)0.745
 Diuretics39 (77)25 (81)7 (88)7 (58)0.219
 Inotropic 37 (71)23 (72)5 (63)9 (75)0.824
Inotropic equivalents, 5 (0–10)4 (0–9)4 (0–8)9 (1–13)0.335
IABP, (%)22 (43)13 (42)2 (25)7 (58)0.329
WBC, 109/L8.4 (7.1–11.4)8.8 (7.2–11.9)8.5 (5.6–17.2)8.4 (6.5–9.4)0.580
INR1.2 (1.1–1.4)1.2 (1.0–1.5)1.2 (1.1-1.2)1.2 (1.1–1.4)0.407
Lactate, mg/dL1.0 (0.8–1.8)1.2 (0.8–1.7)1.0 (0.7–1.8)1.0 (0.8–2.8)0.814
eGFR, mL/min/1.73 m280 (58–100)86 (74–116)57 (50–76)*59 (42–76)*0.001
t-Bil, mg/dL1.04 (0.63–1.86)0.98 (0.61–1.89)1.28 (0.89–2.37)0.84 (0.57–1.91)0.482
tSOFA score, 5 (3–7)4 (2–6)5 (3–7)6 (5–10)0.051
Perioperative data
 Surgery time, min310 (255–375)308 (270–368)340 (308–383)275 (213–390)0.312
 CPB time, min83 (68–102)81 (65–104)88 (68–122)84 (72–96)0.828

Data are expressed as median and interquartile range (25th–75th) or number (percentage).
ACEi: angiotensin converting enzyme inhibitor; t-Bil: total Bilirubin; BUN: blood urea nitrogen; CI: cardiac index; CPB: cardiopulmonary bypass; DCM: dilated cardiomyopathy; ECMO: extracorporeal membrane oxygenation; eGFR: estimated glomerular filtrate rate; IABP: intra-aortic balloon pump; ICM: ischemic cardiomyopathy; INR: international normalized ratio; INTERMACS: Interagency Registry for Mechanically Assisted Circulatory Support; LVEF: left ventricular ejection fraction; LVEDV: left ventricular end-diastolic volume; MAP: mean arterial pressure; PCWP: pulmonary capillary wedge pressure; RAP: right atrial pressure; tSOFA: total sequential organ failure assessment; WBC: white blood cell count; +: positive; −: negative.
versus group A patients by Bonferroni post-hoc test.