Tumor Necrosis Factor-α-Induced Colitis Increases NADPH Oxidase 1 Expression, Oxidative Stress, and Neutrophil Recruitment in the Colon: Preventive Effect of Apocynin
Figure 1
Apocynin improves TNFα-induced macroscopic damage of the colon. (a) Macroscopic examination of the colon of mice treated with TNFα (10 μg · kg−1, ip) in the presence or absence of apocynin (25 mg · kg−1, ip). Apocynin was given 30 min before TNFα administration. Colons were resected at 6, 18, and 36 hr after TNFα treatment. Control mice were given saline and sacrificed at 36 hr; (b) macroscopic score damage in the colon of mice treated with TNFα (10 μg · kg−1, ip) in the presence or absence of apocynin (25 mg · kg−1, ip). Results from mice treated with 10 μg kg−1 TNFα were matched to control mice with Mann-Whitney’s test. Values are means ± SEM from mice in each group. and versus control group; and versus TNFα treated group.
