Tumor Necrosis Factor-α-Induced Colitis Increases NADPH Oxidase 1 Expression, Oxidative Stress, and Neutrophil Recruitment in the Colon: Preventive Effect of Apocynin
Figure 5
Apocynin decreases neutrophils infiltration and KC level in the colon of TNFα-treated mice. (a) Neutrophils infiltration was determined by measuring MPO activity, as described in Section 2, in the colon of mice treated with TNFα (10 μg · kg−1, ip) in the presence or absence of apocynin (25 mg · kg−1, ip). Data are expressed as means ± S.E.M from mice in each group. , , and versus control; , , and versus TNFα; (b) KC level was measured by ELISA in the colon of mice treated with TNFα (10 μg · kg−1, ip) in the presence or absence of apocynin (25 mg · kg−1, ip) as described in Section 2. Data are expressed as means ± S.E.M from mice in each group. , , and versus control; , , and versus TNFα.
