Active Smoking Increases Microsomal PGE₂-Synthase-1/PGE-Receptor-4 Axis in Human Abdominal Aortic Aneurysms

Figure 2

(a) Representative immunohistochemical images of mPGES-1 in aorta samples from current smokers (CS, left) and noncurrent smokers (N-CS, right) patients, showing mPGES-1 immunostaining of MVEC (A, A′), VSMC of the media layer (B, B′), and mPGES-1 positive leukocytes (C, C′). Red arrow-ends indicate some immunostained cells. Size bars: 50 μm. (b) Correlation between mPGES-1 transcript levels and those of vascular cell markers; Pearson product moment correlation applied to log 10-transformed data (𝑛=89).

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