Tumour Necrosis Factor Superfamily Members in the Pathogenesis of Inflammatory Bowel Disease
Figure 1
Two major mechanisms which implicate the molecules belonging to the TNFSF in the pathomechanisms of IBD. (a) Disruption of intestinal epithelium integrity allows luminal bacterial antigens to cross the epithelial barrier and migrate into the intestinal mucosa where they elicit immune responses. (b) Activation of mucosa-infiltrating T lymphocytes.
