Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models
Figure 2
ASO-mediated lowering of CRP in rats subjected to coronary artery ligation improves myocardial infarction (MI) induced cardiac dysfunction. LV function was measured by echocardiographic analysis in rats at baseline and at 1 wk after MI. Heart rate (HR), LV end-systolic dimension (LVESD), LV end-diastolic dimension (LVEDD), ejection fraction (EF), fractional shortening (FS), and the mean velocity of circumferential shortening (VCFR) were calculated as described in the Materials and Methods. The results shown are for rats treated with ISIS 197178 versus controls (see the Results section for details). Single and double asterisks indicate and for unpaired -tests.
