Osteopontin Expression in the Brain Triggers Localized Inflammation and Cell Death When Immune Cells Are Activated by Pertussis Toxin

Table 1

Gene transcripts that were significantly changed in the lesion site following the injection with OPN-encoding adenoviral vector, in comparison to β-gal.

Gene name	Gene symbol	Fold change OPN/β-gal	value
Secreted phosphoprotein 1	SPP1 (OPN)	505.54	0
Interleukin 13 receptor, alpha 1	IL13Rα1	2.29	0.0083
Chemokine (C-X-C motif) receptor 3	CXCR3	2.39	0.0153
Toll interacting protein	TOLLIP	0.75	0.0178
Interleukin 2 receptor, gamma chain	IL2R	2.37	0.0237
Integrin beta 2	ITGβ2	1.41	0.0329
CD40 ligand	CD40L	3.39	0.0348
Chemokine (C-X3-C motif) ligand 1	CX3CL1 (Fraktalkine)	0.55	0.0374

Fold change and value of gene expression induced by OPN-in relation to β-gal-injected sites were calculated from qRT-PCR data, which was obtained from the examination of 84 genes assembled in a commercially available qPCR array, as described in Material and Methods. The genes are sorted according to significance.