Adiponectin and Atherosclerosis in Rheumatoid Arthritis

Table 3

Independent relationships of total adiponectin concentrations (1 SD increment) with carotid atherosclerosis in all RA patients and subgroups.

Groups	cIMT		Plaque
	Partial 𝑅	𝑃	OR (95% CI)	𝑃
All	0.042	0.6	0.98 (0.91–1.05)	0.6
Population
Black	−0.153	0.1	1.08 (0.94–1.30)	0.9
White	0.131	0.2	0.89 (0.77–1.01)	0.07
Age >55 years
Yes	0.031	0.8	0.98 (0.89–1.07)	0.07
No	0.023	0.8	0.92 (0.75–1.02)	0.08
≥1 major risk factors
Yes	−0.023	0.9	0.95 (0.89–1.01)	0.09
No	0.041	0.6	1.05 (0.90–1.02)	0.5
Obesity
Yes	0.068	0.6	0.93 (0.84–1.02)	0.1
No	0.040	0.7	0.99 (0.90–1.09)	0.9
MetS waist
Yes	0.112	0.3	0.87 (0.76–0.99)	0.02
No	0.003	1.0	1.08 (0.92–1.13)	0.7
RA duration >10 years
Yes	0.129	0.2	0.94 (0.83–1.03)	0.2
No	−0.078	0.5	1.05 (0.94–1.15)	0.4
CDAI >10
Yes	−0.017	0.9	0.92 (0.78–1.06)	0.2
No	0.090	0.4	0.99 (0.90–1.08)	0.7
ESR >12
Yes	−0.072	0.5	0.96 (0.84–1.08)	0.4
No	0.129	0.2	0.97 (0.87–1.08)	0.6
Deformed joints
Yes	0.068	0.4	1.00 (0.90–1.10)	0.9
No	−0.193	0.2	0.94 (0.88–0.99)	0.03
Rheumatoid factor positive
Yes	0.023	0.8	0.99 (0.94–1.04)	0.9
No	0.091	0.6	0.91 (0.72–1.10)	0.3

Relationships were determined in Framingham score, race, glomerular filtration rate, waist circumference, and C-reactive protein concentrations adjusted models. Significant associations are shown in bold. SD: standard deviation; cIMT: carotid intima-media thickness; OR: odds ratio; CI: confidence interval; RA: rheumatoid arthritis; MetS: metabolic syndrome; CDAI: Clinical Disease Activity Index; ESR: erythrocyte sedimentation rate.