Adiponectin and Atherosclerosis in Rheumatoid Arthritis

Table 4

Independent relationships of high molecular weight adiponectin concentrations (1 SD increment) with carotid atherosclerosis in all RA patients and subgroups.

Groups	cIMT		Plaque
	Partial 𝑅	𝑃	OR (95% CI)	𝑃
All	−0.008	0.9	0.99 (0.96–1.02)	0.6
Population
Black	−0.173	0.08	1.04 (0.94–1.33)	0.9
White	0.071	0.5	0.96 (0.95–1.01)	0.1
Age >55 years
Yes	−0.057	0.6	0.99 (0.94–1.04)	0.07
No	0.008	0.9	0.95 (0.91–1.01)	0.1
≥1 major risk factors
Yes	−0.042	0.8	0.96 (0.92–1.01)	0.07
No	−0.035	0.7	1.01 (0.95–1.12)	0.4
Obesity
Yes	−0.008	1.0	0.96 (0.90–1.01)	0.1
No	−0.011	0.9	1.00 (0.96–1.05)	1.0
MetS waist
Yes	−0.035	0.7	0.92 (0.85–0.99)	0.02
No	−0.006	1.0	1.02 (0.94–1.06)	0.6
RA duration >10 years
Yes	0.059	0.6	0.97 (0.92–1.02)	0.2
No	−0.091	0.4	1.02 (0.97–1.07)	0.5
CDAI >10
Yes	0.005	1.0	0.94 (0.86–1.02)	0.2
No	−0.002	1.0	1.00 (0.96–1.04)	0.9
ESR >12
Yes	−0.013	0.9	0.96 (0.84–1.08)	0.3
No	0.038	0.7	0.99 (0.96–1.04)	0.7
Deformed joints
Yes	0.018	0.8	1.00 (0.96–1.05)	0.8
No	−0.140	0.4	0.94 (0.89–0.99)	0.03
Rheumatoid factor positive
Yes	0.008	0.9	1.00 (0.96–1.03)	0.8
No	−0.024	0.9	0.96 (0.86–1.05)	0.3

Relationships were determined in Framingham score, race, glomerular filtration rate, waist circumference, and C-reactive protein concentrations adjusted models. Significant associations are shown in bold. SD: standard deviation; cIMT: carotid intima-media thickness; OR: odds ratio; CI: confidence interval; RA: rheumatoid arthritis; MetS: metabolic syndrome; CDAI: Clinical Disease Activity Index; ESR: erythrocyte sedimentation rate.