Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Figure 1

An overview of the pathogenesis of oral mucositis. RT: radiotherapy, ROS: reactive oxygen species, CT: chemotherapy, NF-𝜅B: nuclear factor-kappa B, IL: interleukin, TNF-𝛼: tumor necrosis factor-alpha, COX-2: cyclooxygenase-2, and MMP: matrix metalloproteinase. Courtesy of Professor ST Sonis and the Multinational Association of Supportive Care in Cancer (MASCC).