α-Lipoic Acid Inhibits Helicobacter pylori-Induced Oncogene Expression and Hyperproliferation by Suppressing the Activation of NADPH Oxidase in Gastric Epithelial Cells
Figure 3
Effect of α-LA on cell proliferation of H. pylori-infected AGS cells. The cells were pretreated with α-LA for 2 h and cultured in the presence or absence of H. pylori. Cell proliferation was assessed by viable cell numbers and thymidine incorporation. (a) Viable cell numbers were determined by trypan blue exclusion assay for the indicated time period. (b) The cells were treated with thymidine at 24 h after H. pylori infection and incubated for 8 h. The amount of thymidine incorporation of AGS cells cultured in the absence of H. pylori is considered as 100%. versus corresponding none (the cells cultured in the absence of H. pylori); + versus corresponding H. pylori control (the cells cultured in the presence of H. pylori and treated without α-LA).
