Expression of Toll-Like Receptors 3, 7, and 9 in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

Table 3

The percentage of TLR9-positive PBMCs, lymphocytes B CD19⁺, and lymphocytes T CD3⁺ in relation to SLICC/ACR organ damage.

Cells subpopulations; (% positive cells)	SLICC = 0; 𝑛=13; (a)	SLICC = 1; 𝑛=14; (b)	SLICC = 2; 𝑛=5; (c)	Healthy; 𝑛=15; (d)	Statistical significance
TLR9 in PBMC
𝑥±SD	𝟑𝟏.𝟎𝟒±31.93	𝟑𝟓.𝟎𝟐±33.89	𝟓𝟖.𝟕𝟗±27.01	1.09±0.75	(a)–(d) 𝑃<0.003
Median	13.92	27.30	64.40	1.10	(b)–(d) 𝑃<0.001
Range	(0.72–97.5)	(0.3–98.37)	(27.75–93.53)	(0.05–2.50)	(c)-(d) 𝑃<0.001
TLR9 in CD3
𝑥±SD	𝟏𝟒.𝟒𝟕±21.71	𝟐𝟐.𝟖𝟖±32.12	𝟐𝟖.𝟖𝟏±26.21	3.14±7.85
Median	4.26	1.98	23.58	0.75
Range	(0.36–66.9)	(0.4–80.44)	(5.37–62.73)	(0.00–30.18)
TLR9 in CD19
𝑥±SD	𝟐.𝟔𝟗±2.19	𝟔.𝟎𝟒±7.59	𝟗.𝟗𝟓±7.62	0.78±0.95	(c)-(d) 𝑃<0.006
Median	3.25	3.02	10.29	0.45
Range	(0.1–6.52)	(0.10–26.00)	(3.32–22.0)	(0.00–3.00)

𝑥: mean; SD: standard deviation.
The bold font emphasises that the higher SLICC value is parallelled with the higher percentage of PBMCs, lymphocytes CD3+ and CD19+ with TLR9.