Association of Myeloid Cells of Triggering Receptor-1 with Left Ventricular Systolic Dysfunction in BALB/c Mice with Sepsis

Figure 1

mAbTREM-1 deteriorates left ventricular systolic function in mice following LPS treatment. (12a), (12b), and (12c) represent M-mode echocardiograms among 3 groups at 12 h, respectively. Bar graphs demonstrating differences in echocardiographic left ventricular parameters (LVEDd, LVESd, FS, EF) at 6 h ((6A)–(6D)), 12 h ((12A)–(12D)), and 24 h ((24A)–(24D)) among 3 groups as described in Materials and Methods; LVESd: left ventricular end-systolic diameter, LVEDd: left ventricular end-diastolic diameter, FS: fractional shortening (%), and EF: ejection fraction (%); data are expressed as MEAN ± SEM; ^#𝑃<0.05 compared with saline-treated mice, ^∗𝑃<0.05 compared with saline-treated mice, and ^&𝑃<0.05 compared with LPS-treated mice.