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Mediators of Inflammation
Volume 2014 (2014), Article ID 392062, 10 pages
http://dx.doi.org/10.1155/2014/392062
Research Article

A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model

1School of Pharmaceutical Science and Technology, Tianjin University, Office A508, Building 24, 92 Weijin Road, Nankai District, Tianjin 300072, China
2Haidian Maternal & Child Health Hospital of Beijing, China

Received 14 July 2014; Accepted 20 August 2014; Published 13 October 2014

Academic Editor: Julio Galvez

Copyright © 2014 Liqun Chi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Parolini, L. Souza-Moreira, F. O'Valle et al., “Therapeutic effect of human amniotic membrane-derived cells on experimental arthritis and other inflammatory disorders,” Arthritis & Rheumatology, vol. 66, pp. 327–339, 2014. View at Google Scholar
  2. C. Bombardier, M. Barbieri, A. Parthan et al., “The relationship between joint damage and functional disability in rheumatoid arthritis: a systematic review,” Annals of the Rheumatic Diseases, vol. 71, no. 6, pp. 836–844, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. F. M. Brennan and I. B. McInnes, “Evidence that cytokines play a role in rheumatoid arthritis,” Journal of Clinical Investigation, vol. 118, no. 11, pp. 3537–3545, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Y. Chiang, G. A. Kolumam, X. Yu et al., “Targeted depletion of lymphotoxin-α-expressing TH1 and TH17 cells inhibits autoimmune disease,” Nature Medicine, vol. 15, no. 7, pp. 766–773, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Hu, L. Shi, R. Mu et al., “Hypoxia-inducible factor-1α and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis,” PLoS ONE, vol. 8, Article ID e72650, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. S. E. Gabriel and K. Michaud, “Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases,” Arthritis Research and Therapy, vol. 11, no. 3, article 229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Sokka, “Work disability in early rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 21, no. 5, pp. S71–S74, 2003. View at Google Scholar · View at Scopus
  8. M.-H. Liu, J.-S. Sun, S.-W. Tsai, S.-Y. Sheu, and M.-H. Chen, “Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation,” Nutrition Research, vol. 30, no. 1, pp. 57–65, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. C.-Q. Xu, B.-J. Liu, J.-F. Wu et al., “Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NFκB signaling pathway,” European Journal of Pharmacology, vol. 642, no. 1–3, pp. 146–153, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Zhou, J. Wu, X. Chen et al., “Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions,” International Immunopharmacology, vol. 11, no. 7, pp. 890–898, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. Y.-H. Song, H. Cai, N. Gu, C.-F. Qian, S.-P. Cao, and Z.-M. Zhao, “Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure,” Journal of Pharmacy and Pharmacology, vol. 63, no. 4, pp. 541–549, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Sun, Y. Liu, X. Deng et al., “An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis,” Phytomedicine, vol. 20, no. 11, pp. 975–979, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. J.-S. Park, S.-K. Kwok, M.-A. Lim et al., “TWEAK promotes osteoclastogenesis in rheumatoid arthritis,” The American Journal of Pathology, vol. 183, no. 3, pp. 857–867, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. J. S. Park, S. K. Kwok, M. A. Lim et al., “STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis,” Arthritis & Rheumatology, vol. 66, no. 4, pp. 918–929, 2014. View at Google Scholar
  15. J. S. Park, M. A. Lim, M. L. Cho et al., “P53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/treg cell balance in mice,” Arthritis and Rheumatism, vol. 65, no. 4, pp. 949–959, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. J.-S. Park, M.-K. Park, H.-J. Oh et al., “Grape-seed proanthocyanidin extract as suppressors of bone destruction in inflammatory autoimmune arthritis,” PLoS ONE, vol. 7, no. 12, Article ID e51377, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Lorenzo, M. Horowitz, and Y. Choi, “Osteoimmunology: Interactions of the bone and immune system,” Endocrine Reviews, vol. 29, no. 4, pp. 403–440, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. S. H. Lee, T. S. Kim, Y. Choi, and J. Lorenzo, “Osteoimmunology: cytokines and the skeletal system,” Journal of Biochemistry and Molecular Biology, vol. 41, no. 7, pp. 495–510, 2008. View at Google Scholar · View at Scopus
  19. J. Morko, R. Kiviranta, K. Joronen, A.-M. Säämänen, E. Vuorio, and H. Salminen-Mankonen, “Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K,” Arthritis & Rheumatism, vol. 52, no. 12, pp. 3713–3717, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Jerome, M. Missbach, and R. Gamse, “Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys,” Osteoporosis International, vol. 23, no. 1, pp. 339–349, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Svelander, H. Erlandsson-Harris, L. Astner et al., “Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice,” European Journal of Pharmacology, vol. 613, no. 1-3, pp. 155–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Bettelli, M. Oukka, and V. K. Kuchroo, “TH-17 cells in the circle of immunity and autoimmunity,” Nature Immunology, vol. 8, no. 4, pp. 345–350, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. C. Genovese, F. van den Bosch, S. A. Roberson et al., “LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study,” Arthritis and Rheumatism, vol. 62, no. 4, pp. 929–939, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Laurence, C. M. Tato, T. S. Davidson et al., “Interleukin-2 signaling via STAT5 constrains T helper 17 cell generations,” Immunity, vol. 26, no. 3, pp. 371–381, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. X. O. Yang, A. D. Panopoulos, R. Nurieva et al., “STAT3 regulates cytokine-mediated generation of inflammatory helper T cells,” Journal of Biological Chemistry, vol. 282, no. 13, pp. 9358–9363, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Durant, W. T. Watford, H. L. Ramos et al., “Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis,” Immunity, vol. 32, no. 5, pp. 605–615, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. T. J. Harris, J. F. Grosso, H.-R. Yen et al., “An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity,” Journal of Immunology, vol. 179, no. 7, pp. 4313–4317, 2007. View at Publisher · View at Google Scholar · View at Scopus