Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study
Table 3
Cohort analysis: age- and sex-adjusted baseline characteristics of the subjects according to categories of peripheral blood leukocyte counts ( = 13,061)1.
Categories of peripheral blood leukocyte counts (range: ×1,000 cells/mm3)
for trend2
Subnormal (1.1–3.9)
Level 2 (4.0–4.9)
Level 3 (5.0–5.9)
Level 4 (6.0–6.9)
Level 5 (7.0–7.9)
Level 6 (8.0–8.9)
Level 7 (9.0–9.9)
Above-normal (10.0–14.5)
Age (y)
44.8 (44.0, 45.5)3
43.9 (43.5, 44.3)
43.1 (42.7, 43.5)
43.0 (42.6, 43.5)
42.5 (41.8, 43.2)
43.9 (43.0, 44.8)
<0.0001
Sex (male, %)
36.8
49.2
58.9
64.4
66.6
75.2
<0.0001
BMI (kg/m2)
23.0 (22.8, 23.2)
23.5 (23.4, 23.6)
24.1 (24.0, 24.2)
24.6 (24.4, 24.7)
24.8 (24.7, 25.0)
24.8 (24.6, 25.1)
<0.0001
Waist circumference (cm)
78.1 (77.6, 78.5)
79.4 (79.2, 79.7)
80.9 (80.7, 81.2)
82.0 (81.6, 82.3)
82.8 (82.3, 83.2)
83.1 (82.5, 83.6)
<0.0001
TC (mmol/L)
4.94 (4.88, 4.99)
5.00 (4.97, 5.03)
5.03 (5.00, 5.06)
5.07 (5.03, 5.10)
5.07 (5.02, 5.12)
5.08 (5.01, 5.14)
<0.01
TG (mmol/L)
1.00 (0.95, 1.05)
1.11 (1.08, 1.13)
1.23 (1.20, 1.25)
1.31 (1.28, 1.34)
1.36 (1.31, 1.41)
1.47 (1.41, 1.52)
<0.0001
LDL (mmol/L)
2.94 (2.89, 2.98)
2.99 (2.97, 3.02)
3.01 (2.99, 3.04)
3.05 (3.02, 3.08)
3.06 (3.01, 3.10)
3.01 (2.95, 3.07)
<0.01
HDL (mmol/L)
1.58 (1.56, 1.59)
1.54 (1.53, 1.55)
1.50 (1.49, 1.51)
1.47 (1.45, 1.48)
1.43 (1.41, 1.45)
1.45 (1.43, 1.47)
<0.0001
SBP (mmHg)
115.2 (114.4, 116)
116.3 (115.8, 116.8)
117.5 (117.1, 117.9)
117.5 (116.9, 118.0)
118.2 (117.4, 119.0)
117.4 (116.4, 118.4)
<0.0001
DBP (mmHg)
73.3 (72.7, 73.8)
74.1 (73.8, 74.4)
74.8 (74.6, 75.1)
75.2 (74.9, 75.6)
75.3 (74.8, 75.8)
75.3 (74.6, 76.0)
<0.0001
FBS (mmol/L)
4.75 (4.71, 4.79)
4.76 (4.74, 4.79)
4.76 (4.73, 4.78)
4.75 (4.73, 4.78)
4.71 (4.67, 4.75)
4.69 (4.64, 4.75)
0.72
Serum UA (mol/L)
283.2 (279.4, 286.9)
290.3 (288.2, 292.5)
299.0 (297.0, 301.0)
302.2 (299.7, 304.6)
305.6 (301.9, 309.3)
303.1 (298.4, 307.9)
<0.0001
Fibrinogen (g/L)
2.63 (2.6, 2.66)
2.67 (2.65, 2.68)
2.68 (2.66, 2.69)
2.71 (2.69, 2.73)
2.72 (2.69, 2.75)
2.80 (2.77, 2.84)
<0.01
Albumin (g/L)
46.0 (45.8, 46.2)
46.0 (45.9, 46.1)
45.9 (45.8, 46.0)
45.7 (45.6, 45.9)
45.7 (45.5, 45.9)
45.4 (45.1, 45.6)
0.41
Smoking status (%)
Smoker
11.0
16.6
22.6
31.1
40.5
54.9
<0.0001
Ex-smoker
0.00
0.03
0.02
0.00
0.00
0.14
0.23
Drinker (%)
19.8
26.7
32.7
35.2
36.9
43.2
<0.001
Family history of diseases (%)
CVD
35.5
34.8
33.3
31.7
33.3
34.1
0.74
Hypertension
49.0
47.4
49.5
48.8
47.6
48.2
0.52
Hyperlipidemia
1.25
1.18
1.05
1.14
0.76
0.56
0.16
Diabetes
15.9
17.5
18.5
19.7
21.0
22.7
<0.0001
BMI: body mass index; TC: total cholesterol; TG: triglycerides; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol; SBP: systolic blood pressure; DBP: diastolic blood pressure; FBS: fasting blood sugar; UA: uric acid; CVD: cardiovascular disease.
2Analysis of covariance or logistic regression analysis adjusted for age and sex where appropriate.
3Adjusted least squares mean (95% confidence interval) (all such values).
