Pentraxin 3 as a Prognostic Biomarker in Patients with Systemic Inflammation or Infection

Table 3

Prognostic value of PTX3 to predict mortality as compared to other biological markers and disease severity scores.

Ability to predict	Parameter	AUC (95% CI)	Cutoff	Sensitivity (%)	Specificity (%)	References
General intensive care unit population
	PTX3	0.63	—	—	—
	IL-6	0.72	—	—	—
ICU mortality	CRP	0.55	—	—	—	[15]
	CTpr	0.61	—	—	—
	SAPSII	0.76	—	—	—
90-Day mortality	PTX3 (day 5 : day 1)	0.73	0.76	64	72	[20]
	CRP (day 5 : day 1)	0.58	—	—	—
	IL-6 (day 5 : day 1)	0.63	—	—	—
	IF-α (day 5 : day 1)	0.61	—	—	—
Patients with infectious diseases
	PTX3	0.69 (CI 0.58–0.79)	7.7 ng/mL	70	63
28-Day mortality	PCT	0.65 (CI 0.57–0.74)	0.19 ng/mL	82	63	[25]
	CRP	0.50 (CI 0.38–0.62)	—	—	—
Bacteremic patients
30-Day mortality	PTX3 (the maximum value on days 1 to 4)	0.82 (CI 0.73–0.91)	15 ng/mL	72	81	[22]
	CRP (the maximum value on days 1 to 4)	0.61 (CI 0.49–0.73)	—	—	—
	PTX3	0.781 ± 0.065	>44.45 ng/mL	64.7	88.4
28-Day mortality	CRP	0.635 ± 0.071	>135.7	64.7	62.3	[26]
	PTX3 + CRP	0.863 ± 0.041	—	—	—