Mediators of Inflammation / 2014 / Article / Tab 1 / Review Article
Adipokines as Potential Biomarkers in Rheumatoid Arthritis Table 1 Correlation of adipokines with disease activity parameters and therapeutic response.
Adipokine Correlation with DAS28 BMI IL-6/TNF/ESR Anti-CCP Radiographic progression Therapeutic response Adiponectin pos [30 ] neg [31 ] pos [30 ] neg [31 ] pos [27 , 31 ] Anti-TNF: pos [32 , 33 ] Leptin pos [46 ] neg [46 ] neg [31 ] no [31 ] neg [98 ] Anti-TNF: neg [52 ] Chemerin pos [80 ] neg, pos [80 ] pos [78 ] ND ND Anti-TNF: pos [81 ] Visfatin neg [102 ] neg [149 ] pos [31 ] pos [31 ], neg [102 ] pos [100 ] Anti-TNF: neg [101 ], pos [91 ]102 ] Resistin pos [30 ] pos [31 ] pos [31 , 118 ] No in serum but pos in SF [111 ] ND Anti-TNF: pos [118 ] Lipocalin 2 ND ND ND ND ND ND SAA3 ND ND ND ND ND ND Vaspin SF pos [150 ] pos [147 ] SF neg [150 ] SF neg [150 ] ND ND Omentin SF neg [150 ] neg [152 ] SF neg [150 ] SF pos [150 ] ND ND Apelin ND ND ND ND ND DMARDs: neg [158 ] Adipsin ND pos [31 ] pos [31 ] ND neg [31 ] DMARDs: pos [160 ]
Abbreviations: pos: positive; neg: negative; SF: synovial fluid; ND: not determined. Where not specified, the correlations are referred to serum levels. Positive correlation with therapeutic response is assumed when the adipokine levels are modified (either they increase or decrease) by the treatment.
