Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae
Enhanced proliferation of CD4 and CD8 T cells by CPn-stimulated DCs from aged subjects in an allogeneic DC-T cell coculture. CPn-stimulated and CPn-unstimulated DCs from aged and young subjects were cultured with allogeneic, CFSE labeled T cells from young subjects for 6 days. Graphs depict the proliferation of (a) CD4 T cells; (b) CD8 T cells as determined by flow cytometry. Each dot corresponds to a separate subject. Data is of 12 aged and 9 young subjects for (a) and 11 aged and 8 young for (b). value depicted is comparison of CPn-stimulated DCs with unstimulated DCs for both aged and young subjects.