Mediators of Inflammation / 2014 / Article / Fig 7

Research Article

Protective Effects of Pretreatment with Oleanolic Acid in Rats in the Acute Phase of Hepatic Ischemia-Reperfusion Injury: Role of the PI3K/Akt Pathway

Figure 7

Proposed schematic flow of OA’s role in attenuating hepatic IR injury. IR procedure induces activation of PI3K cascades and then results in increases in IL-1 and ALT in the serum. OA can further activate these molecular changes at the PI3K/Akt signaling pathway and results in the decreased serum ALT activity and IL-1 concentration.

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