The Impact of Staphylococcus aureus-Associated Molecular Patterns on Staphylococcal Superantigen-Induced Toxic Shock Syndrome and Pneumonia
Figure 5
Effect of S. aureus-derived PAMPs on SEB-induced T cell expansion in vivo. HLA-DR3 transgenic mice were challenged with staphylococcal enterotoxin B (SEB) alone (10 μg), staphylococcal peptidoglycan (PGN) alone (50 μg), or lipoteichoic acid (LTA, 50 μg), SEB with PGN or SEB with LTA. Animals were killed 3 days later and distribution of T cells expressing TCR Vβ families were determined by flow cytometry. Mean ± SE from 5–8 mice in each group. compared to naïve mice. = NS between SEB versus SEB + PGN, SEB versus SEB + LTA, and SEB + LTA versus SEB + PGN.
