Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice

Figure 3

Cardiac histopathology after treatment with pyridostigmine bromide. Photomicrographs of cardiac sections stained with H-E. Panels (a) and (b): ventricular sections from a control nontreated mouse. Panels (c) and (d): ventricular sections from a pyridostigmine bromide-treated control mouse. Panels (e) and (f): ventricular sections from a chagasic nontreated mouse. Panels (g) and (h): atrial sections from a nontreated chagasic mouse showing, respectively, a ganglionitis and neuritis focus. Panels (i), (j), (k), and (l): different ventricular sections from a chagasic mouse treated with pyridostigmine bromide. Note the lower inflammatory infiltration into heart tissues from a chagasic mouse treated with pyridostigmine bromide. (Left panels: magnification = 100x; right panels: magnification = 200x.)