Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice

Figure 4

Cardiac fibrosis after treatment with pyridostigmine bromide. Fibrotic areas (in μm²) expressed as mean ± S.E.M. for the right (Panel (a)) and left (Panel (b)) atria, the right (Panel (c)) and left (Panel (d)) ventricles, and the atrioventricular septum (Panel (e)), measured after Picrosirius Red staining at the 6th month of observation and after one month of treatment (from the 5th to 6th month of infection) in noninoculated control (Con) or in T. cruzi-inoculated (Chg) C57BL/6j mice treated with pyridostigmine bromide (Pyrido) or vehicle (NT: nontreated animals). ( versus Con-NT; versus Chg-Pyrido; and versus Con-Pyrido).

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