Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice

Table 1

Electrocardiogram before treatment with pyridostigmine bromide. Electrocardiographical parameters (expressed as mean ± S.E.M.) collected after five months follow-up in noninoculated control (Con) or T. cruzi-inoculated (Chg) anesthetized C57BL/6j mice before treatment with pyridostigmine bromide (Pyrido) or vehicle (NT: nontreated animals).

	Con-NT	Con-Pyrido	Chg-NT	Chg-Pyrido
RR (ms)	139.73 ± 5.22	150.83 ± 6.02	139.04 ± 5.62	133.35 ± 4.04
Pd (ms)	13.87 ± 1.50	13.8 ± 1.37	18.56 ± 0.51^*#	18.84 ± 0.72^*#
PR (ms)	38.83 ± 2.61	38.72 ± 2.28	40.64 ± 0.98	40.17 ± 1.29
QRSd (ms)	14.6 ± 1.86	13.61 ± 1.43	17.53 ± 1.08^*#	17.06 ± 1.00^*#
QT (ms)	20.74 ± 2.26	17.14 ± 1.60	22.28 ± 0.96^*#	21.2 ± 1.01^#
cQT (ms^1/2)	1.74 ± 0.51	1.42 ± 0.50	1.9 ± 0.08^*#	1.84 ± 0.09^#

RR: RR interval; Pd: P wave duration; PR: PR interval; QRSd: QRS complex duration; QT: QT interval; cQT: corrected QT interval; ms: milliseconds; versus Con-NT; and versus Con-Pyrido.