Deregulation of Annexin-A1 and Galectin-1 Expression in Precancerous Gastric Lesions: Intestinal Metaplasia and Gastric Ulcer

Table 2

Relative gene expression of ANXA1 and LGALS1 mRNA in the intestinal metaplasia (IM) and gastric ulcer (GU) groups and comparison according to risk factors.

Variables	ANXA1				LGALS1
	IM		GU		IM		GU
	(𝑁=36)		(𝑁=29)		(𝑁=36)		(𝑁=29)
mRNA
Mean ± SD	6.22±1.43		6.69±1.56		0.35±1.37		0.69±1.65
(range)	(2.55–8.90)		(2.42–8.80)		(−3.54–2.86)		(−4.04–3.13)
𝑃	0.21				0.38
Age (years)
	<60	16 (44.5%)	<55	15 (51.7%)	<60	16 (44.5%)	<55	15 (51.7%)
(Mean ± SD)		6.48±1.55		6.81±1.71		0.62±1.11		0.63±1.84
	≥60	20 (55.5%)	≥55	14 (48.3%)	≥60	20 (55.5%)	≥55	14 (48.3%)
(Mean ± SD)		6.00±1.32		6.55±1.43		0.14±1.53		0.76±1.50
𝑃	0.34		0.66		0.28		0.83
Gender
Female	19 (52.8%)		8 (27.6%)		19 (52.8%)		8 (27.6%)
(Mean ± SD)	6.30±1.34		7.07±1.18		0.80±1.30		1.41±1.26
Male	17 (47.2%)		21 (72.4%)		17 (47.2%)		21 (72.4%)
(Mean ± SD)	6.12±1.55		6.54±1.69		−0.15±1.29		0.42±1.73
𝑃	0.71		0.35		0.03*		0.11
Drinking
Yes	10 (27.8%)		11 (39.3%)		10 (27.8%)		11 (39.3%)
(Mean ± SD)	6.12±1.26		6.17±1.97		−0.13±1.75		0.29±1.81
No	26 (72.2%)		17 (60.7%)		26 (72.2%)		17 (60.7%)
(Mean ± SD)	6.26±1.51		7.10±1.17		0.54±1.17		0.88±1.58
𝑃	0.78		0.18		0.29		0.39
Smoking
Yes	26 (72.2%)		18 (64.3%)		26 (72.2%)		18 (64.3%)
(Mean ± SD)	6.26±1.49		6.66±1.64		0.29±1.49		0.46±1.88
No	10 (27.8%)		10 (35.7%)		10 (27.8%)		10 (35.7%)
(Mean ± SD)	6.11±1.32		6.86±1.52		0.53±1.01		0.98±1.21
𝑃	0.76		0.75		0.58		0.39
H. pylori
Positive	14 (38.9%)		15 (55.5%)		14 (38.9%)		15 (55.5%)
(Mean ± SD)	6.70±1.75		6.88±1.35		0.29±1.61		0.94±1.59
Negative	22 (61.1%)		12 (44.5%)		22 (61.1%)		12 (44.5%)
(Mean ± SD)	5.91±1.11		6.47±1.86		0.39±1.23		0.67±1.77
𝑃	0.15		0.53		0.85		0.69
Genotype 𝑐𝑎𝑔𝐴^a
Positive	12 (85.7%)		10 (66.7%)		12 (85.7%)		10 (66.7%)
(Mean ± SD)	6.88±1.81		6.82±1.60		0.45±1.58		0.50±1.68
Negative	2 (14.3%)		5 (33.3%)		2 (14.3%)		5 (33.3%)
(Mean ± SD)	5.58±0.96		6.99±0.81		−0.62±2.12		1.81±1.03
𝑃	0.20		0.77		0.55		0.16

aNonparametric Mann-Whitney test; ∗significant difference.