Mediators of Inflammation

Research Article

Subclinical Inflammatory Status in Rett Syndrome

Table 1

Summary of the proteins identified as differently expressed using the proteomics approach.


Spot	SwissProt code	Protein name	Short name	Theoretical pI/Mr (kDa)	Peptides matches	Sequence coverage (%)	MOWSE score	Biological functions	APR proteins

1^a	P00751	Complement Factor B	CFAB	6.67/86.8	22/39	37	219	Immune system, complement system regulation	(+)
2	P02787	Serum transferrin	TRFE	6.81/79.2	40/80	50	340	Iron binding and transport	(−)
3	P02768	Albumin	ALBU	5.92/71.3	30/62	55	268	Transport, regulation of colloidal osmotic pressure, platelet activation	(−)
4	P02765	Alpha-2-HS-glycoprotein	FETUA	5.43/40.09	10/22	38	110	Endocitosis, opsonization	N.A.^b
5	P01009	Alpha-1-antitrypsin	A1AT	5.37/46.8	16/37	46	164	Acute phase response, coagulation, proteases inhibition	(+)
6	P02679	Fibrinogen gamma chain	FIBG	5.37/52.1	13/43	41	122	Coagulation, signal transduction	(+)
7	P02768	Albumin (C terminal fragment)	ALBU	5.92/71.3	16/29	28	138	Transport, regulation of colloidal osmotic pressure, platelet activation	(−)
8	P00738	Haptoglobin	HPT	6.13/45.8	6/10	14	51	Acute phase response, hemoglobin binding	(+)
9	P01859	Ig gamma-2 chain C region	IGHG2	7.66/36.5	5/8	13	71	Innate immunity	N.A.^b
10	P02766	Transthyretin	TTHY	5.52/15.9	7/18	68	115	Thyroid hormone binding and transport	(−)
11	P02768	Albumin (C terminal fragment)	ALBU	5.92/71.3	18/27	28	188	Transport, regulation of colloidal osmotic pressure, platelet activation	(−)
12	P02647	Apolipoprotein A1	APOA1	5.56/30.7	26/87	65	213	Lipid transport and metabolism	(−)
13	P02753	Retinol-binding protein 4	RET4	5.76/23.3	8/18	57	104	Retinol transport and metabolism	(−)
14	P02768	Albumin (C terminal fragment)	ALBU	5.92/71.3	6/12	12	66	Transport, regulation of colloidal osmotic pressure, platelet activation	(−)
15	P00738	Haptoglobin	HPT	6.13/45.8	8/24	20	86	Acute phase response, hemoglobin binding	(+)
16	P02766	Transthyretin	TTHY	5.52/15.9	6/13	68	104	Thyroid hormone binding and transport	(−)
17	P0DJI8	Serum amyloid A-1 protein	SAA1	6.28/13.5	5/12	51	62	Acute phase response, apolipoprotein of the HDL complex	(+)

Spot numbers match those reported in the representative 2-DE images shown in Figure 3. N.A.: not applicable. (+) and (−) indicate positive and negative APR proteins, respectively. Identified proteins showing variations in RTT for which a possible involvement in the inflammatory response is unknown.