IL-21 Receptor Expression in Human Tendinopathy

Figure 1

IL-21R message and protein in human tendinopathy. (a) The levels of mRNA (2^−ΔΔCT) for IL-21R were determined by real-time PCR in torn tendon and early tendinopathy samples. Data are shown as the mean fold change ± SD of triplicate samples compared to control samples corrected to GAPDH and are representative of experiments using 12 individual donors of tendon tissue (*𝑃<0.05, **𝑃<0.01). (b) Semiquantitative scoring of IL-21R protein expression in tendon samples. Graphs illustrate relative expression of corresponding proteins in human tendon samples. Histological scoring system, 0 = no staining, 1 ≤ 10% cells positive, 2 = 10–20% cells positive, grade 3 ≥ 20% cells positive. Data displayed as mean ± SEM, 𝑛=12 for supraspinatus and matched subscapularis, 𝑛=10 for control group. (*𝑃<0.05, **𝑃<0.01).

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