Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention

Table 4

Heart function related indices.

Variable	Low clopidogrel loading dose (300–450 mg); (𝑛=259)	High clopidogrel loading dose (600 mg); (𝑛=98)	P value
Peak CK (IU/L)	2350.4±1933.7	2046.9±1766.0	0.18
Peak CK-MB (IU/L)	228.2±147.5	210.7±148.9	0.32
Nt-proBNP (pg/mL)	2166.8±2922.0	1112.8±1176.7	<0.0001
Killip class >1 (%)	25.1	12.2	0.01
Echocardiographic findings
Heart rates (beat/min)	75.6±11.3	74.7±9.6	0.28
Atrial fibrillation (%)	21.0	18.6	0.66
On 𝛽-blocker treatment (%)	73.1	70.0	0.33
LVEDd (mm)	49.8±5.1	49.1±4.8	0.26
LVESd (mm)	35.0±5.8	33.4±5.2	0.02
FS (%)	29.9±7.1	31.9±7.5	0.02
LVEF (%)	53.2±8.4	56.4±7.9	0.002
WMSI	1.56±0.21	1.47±0.23	0.001

Values represent mean ± SD or the percent of the patients.
Note: CK: creatine kinase; CK-MB: creatine kinase-MB; Nt-proBNP: N-terminal pro B-type natriuretic peptide; LVEDd: left ventricular end diastolic dimension; LVESd: left ventricular end systolic dimension; FS: fractional shortening; LVEF: left ventricular ejection fraction; WMSI: wall motion score index.