Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice

Table 5

Calpain activity correlates with TLR4 expression and blood loss in postoperative CABG patients.

Calpain-1 expression after surgery	CABG surgery with conventional CPB		CABG surgery with off-pump technique		G1 versus G2; value	G1 versus G3; value	G2 versus G3; value
	G1: active; (patients 9, 12, 14, and 16); (, 23.53%)	G2: inactive; (patients 1, 2, 3, 4, 5, 6, 7, 8, 10, 11, 13, 15, and 17); (, 76.47%)	G3: active; (, 100%)	G4: inactive; (, 0%)
TLR4 expression (% of preincision)				—	<0.05	0.157	<0.001
Drainage loss (mL)				—	<0.05	0.897	<0.001
pRBC transfusion (unit)				—	0.442	0.160	0.031
Platelet transfusion (unit)				—	0.001	0.008	<0.001
ICU stay (day)				—	0.001	0.690	<0.001
ICU fever (hr)				—	0.008	0.739	<0.05

TLR4: Toll-like receptor; pRBC: packed red blood cell; ICU: intensive care unit. The values are shown as the mean ± SD. was considered statistically significant.