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Mediators of Inflammation
Volume 2014, Article ID 485927, 9 pages
http://dx.doi.org/10.1155/2014/485927
Research Article

Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord

1Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen 361003, China
2Huazhong University of Science & Technology, China
3Department of Pharmacology, College of Pharmacy, Fujian Medical University, China
4Division of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, China
5Central Laboratory, The First Affiliated Hospital of Xiamen University, China

Received 17 February 2014; Revised 9 June 2014; Accepted 10 June 2014; Published 24 June 2014

Academic Editor: Bing Du

Copyright © 2014 Ming Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [19 citations]

The following is the list of published articles that have cited the current article.

  • Qingjuan Gong, Zhenhe Lu, Qiaodong Huang, Lin Ruan, Jinsheng Chen, Ying Liang, Honghua Wang, Yu Yue, and Suqin Feng, “Altered microRNAs expression profiling in mice with diabetic neuropathic pain,” Biochemical and Biophysical Research Communications, 2014. View at Publisher · View at Google Scholar
  • Guodong Zheng, Lezhen Lin, Shusheng Zhong, Qingfeng Zhang, and Dongming Li, “Effects of Puerarin on Lipid Accumulation and Metabolism in High-Fat Diet-Fed Mice,” Plos One, vol. 10, no. 3, 2015. View at Publisher · View at Google Scholar
  • Maozhou Gan, and Xiaodong Yin, “Puerarin Induced in Mantle Cell Lymphoma Apoptosis and its Possible Mechanisms Involving Multi-signaling Pathway,” Cell Biochemistry And Biophysics, vol. 71, no. 1, pp. 367–373, 2015. View at Publisher · View at Google Scholar
  • Yunlong Zhang, Tieli Dong, and Li Xia, “Inhibition of MicroRNA-221 Alleviates Neuropathic Pain Through Targeting Suppressor of Cytokine Signaling 1,” Journal of Molecular Neuroscience, vol. 59, no. 3, pp. 411–420, 2016. View at Publisher · View at Google Scholar
  • Yoon Oh, “Bioactive Compounds and Their Neuroprotective Effects in Diabetic Complications,” Nutrients, vol. 8, no. 8, pp. 472, 2016. View at Publisher · View at Google Scholar
  • Md Habibur Rahman, Mithilesh Kumar Jha, and Kyoungho Suk, “Evolving Insights into the Pathophysiology of Diabetic Neuropathy: Implications of Malfunctioning Glia and Discovery of Novel Therapeutic Targets,” Current Pharmaceutical Design, vol. 22, no. 6, pp. 738–757, 2016. View at Publisher · View at Google Scholar
  • Qing-Feng Yu, Hai-Dong Zhang, Yong-Hong Sun, Yun Zhang, Ming Yan, Pei-Fan Yang, Zhi-Fen Zhang, and Yun-Feng Gao, “Puerarin prevents LPS-induced osteoclast formation and bone loss via inhibition of Akt activation,” Biological and Pharmaceutical Bulletin, vol. 39, no. 12, pp. 2028–2035, 2016. View at Publisher · View at Google Scholar
  • Yun-Ming Tu, Xing-Zi Liu, Fang-Fang Hu, Shuo Wang, Shang-Dong Liang, Hong Xu, Cheng-Xin Gong, Lu Ding, Tao Li, and Chao-Peng Xiong, “A high concentration of fatty acids induces TNF-α as well as NO release mediated by the P2X4 receptor, and the protective effects of puerarin in RAW264.7 cells,” Food and Function, vol. 8, no. 12, pp. 4336–4346, 2017. View at Publisher · View at Google Scholar
  • Victoria L. Newton, Jonathan D. Guck, Mary A. Cotter, Norman E. Cameron, and Natalie J. Gardiner, “Neutrophils Infiltrate the Spinal Cord Parenchyma of Rats with Experimental Diabetic Neuropathy,” Journal of Diabetes Research, vol. 2017, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • Saikat Dewanjee, Sonjit Das, Anup Kumar Das, Niloy Bhattacharjee, Anjum Dihingia, Tarun K. Dua, Jatin Kalita, and Prasenjit Manna, “Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets,” European Journal of Pharmacology, 2018. View at Publisher · View at Google Scholar
  • Ajeet Kumar Singh, Sanjay Kumar, and Manjula Vinayak, “Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions,” Inflammation Research, 2018. View at Publisher · View at Google Scholar
  • Xiao Hong Liu, Yuan Shou Chen, DeYing Kong, Hong Tian, Ming Xia Yue, Du Juan Huang, Rui Zhou, Tao Xu, and Jun Wei Zeng, “Activation of spinal dorsal horn P2Y13 receptors can promote the expression of IL-1β and IL-6 in rats with diabetic neuropathic pain,” Journal of Pain Research, vol. 11, pp. 615–628, 2018. View at Publisher · View at Google Scholar
  • Jang Won Lee, and Min Kyung Hyun, “Herbal medicine (Gegen-decoction) for treating cervical spondylosis: A systematic review and meta-analysis of randomized controlled trials,” European Journal of Integrative Medicine, vol. 18, pp. 52–58, 2018. View at Publisher · View at Google Scholar
  • Lifang Zou, Yingxin Gong, Shuangmei Liu, and Shangdong Liang, “Natural compounds acting at P2 receptors alleviate peripheral neuropathy,” Brain Research Bulletin, 2018. View at Publisher · View at Google Scholar
  • Xiuping Chen, Jie Yu, and Jingshan Shi, “ Management of Diabetes Mellitus with Puerarin, a Natural Isoflavone From Pueraria lobata ,” The American Journal of Chinese Medicine, pp. 1–19, 2018. View at Publisher · View at Google Scholar
  • Yi Zhong, Yang-Liang Huang, Yu-Ming Hu, Li-Rong Zhu, and Yuan-Shu Zhao, “Puerarin alleviate radicular pain from lumbar disc herniation by inhibiting ERK-dependent spinal microglia activation,” Neuropeptides, 2018. View at Publisher · View at Google Scholar
  • Heng-Tao Xie, Zhong-Yuan Xia, Xia Pan, Bo Zhao, and Zhi-Gang Liu, “Puerarin ameliorates allodynia and hyperalgesia in rats with peripheral nerve injury,” Neural Regeneration Research, vol. 13, no. 7, pp. 1263, 2018. View at Publisher · View at Google Scholar
  • Jiangju Huang, Xia Liang, Jian Wang, Yan Kong, Zengli Zhang, Zhuofeng Ding, Zongbin Song, Qulian Guo, and Wangyuan Zou, “miR-873a-5p Targets A20 to Facilitate Morphine Tolerance in Mice,” Frontiers in Neuroscience, vol. 13, 2019. View at Publisher · View at Google Scholar
  • Yixiao Wu, Ruichun Wang, and Junping Chen, “Puerarin suppresses TRPV1, calcitonin gene-related peptide and substance P to prevent paclitaxel-induced peripheral neuropathic pain in rats,” NeuroReport, vol. 30, no. 4, pp. 288–294, 2019. View at Publisher · View at Google Scholar