Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord

Figure 2

The effects of puerarin on CCI- and diabetes-induced mechanical allodynia. (a), (c) The temporal profile of mechanical withdrawal threshold on CCI- (a) and diabetes- (c) induced mechanical allodynia; (b), (d) the maximal possible efficiency of puerarin on the 11th day after CCI surgery (b) and the 27th day after streptozotocin injection; CCI: chronic constriction injury. Data are presented as mean ± SEM. ^∗∗∗𝑃<0.001, model group versus control group; ^#𝑃<0.05, ^##𝑃<0.01, ^###𝑃<0.001, puerarin treatment group versus model group (one-way ANOVA with post hoc LSD 𝑡-test). Each group consisted of 6–10 rats.

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