TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA

Figure 4

Effect of capsazepine on peripheral blood CD3⁻NK1.1⁺ and CD3⁺NK1.1⁺ cells. (a) Representative two-colour dot-plots for peripheral blood CD3⁻NK1.1⁺ (NK) and CD3⁺NK1.1⁺ (NKT) cell populations from uninfected and Plasmodium berghei ANKA-infected mice (10⁵ infected RBCs/animal; i.p.). Circulating (b) CD3⁻NK1.1⁺ and (c) CD3⁻NK1.1⁺cell numbers in uninfected and Plasmodium berghei ANKA-infected mice (10⁵ infected RBCs/animal; i.p.). Expression of CD69 on circulating (d) CD3⁻NK1.1⁺ and (e) CD3⁻NK1.1⁺cells. Capsazepine (50 μg/animal, 2x day, for 6 days) was administered from 24 h after infection. Vehicle- (10% DMSO in saline) treated animals were used as controls. Data are expressed as mean ± SD, per group. compared with respective uninfected (control) groups.

(a)

(b)

(c)

(d)

(e)