Lycopene Modulates THP1 and Caco2 Cells Inflammatory State through Transcriptional and Nontranscriptional Processes

Figure 1

Lycopene modulates basal and LPS-induced inflammatory gene expressions in THP1 cells. ICAM-1 (a), IL-1β (b), IL-8 (c), and MMP9 (d) gene expression was studied in THP1 cells treated with LPS. Modulation of this expression was studied in THP1 cell cultures pretreated for 2 h with or without lycopene (2 μM). Then, according to assays, LPS (100 ng/mL) was added for 6 h and mRNA expression was analyzed by RT-qPCR. Values are means ± SD (𝑛=8). Assays treated with lycopene were compared to corresponding assays without lycopene. ^∗∗∗𝑃<0.01; ^∗∗𝑃<0.05; ∗, nonsignificantly different.

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