Lycopene Modulates THP1 and Caco2 Cells Inflammatory State through Transcriptional and Nontranscriptional Processes

Figure 2

Lycopene modulates gene expression induced by PMA and TNF in THP1 cells. ICAM-1 ((a), (e)), IL-1β ((b), (f)), IL-8 ((c), (g)), and MMP9 (d) gene expression was studied in THP1 cells treated with either PMA (a,b,c, and d) or TNFα ((e), (f), and (g)). Modulation of this expression was studied in THP1 cell cultures pretreated for 2 h with or without Lycopene (2 μM). Then, according to assays, PMA (100 nM) or TNFα (10 ng/mL) was added for 6 h and mRNA expression was analyzed by RT-qPCR. Values are means ± SD (𝑛=8). Assays treated with lycopene were compared to corresponding assays without lycopene. ^∗∗∗𝑃<0.01; ^∗∗𝑃<0.05; ∗, nonsignificantly different.

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