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Mediators of Inflammation
Volume 2014 (2014), Article ID 525891, 13 pages
Review Article

Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease

1Vascular Biology Center, Georgia Regents University, Augusta, GA 30912, USA
2Department of Medicine/Vascular Biology Center, CB-3702, Georgia Regents University, 1459 Laney-Walker Boulevard, Augusta, GA 30912, USA

Received 25 March 2014; Revised 1 May 2014; Accepted 12 May 2014; Published 3 June 2014

Academic Editor: Marilia Seelaender

Copyright © 2014 Punithavathi Ranganathan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acute kidney injury (AKI) is a common problem in the hospital setting and intensive care unit. Despite improved understanding, there are no effective therapies available to treat AKI. A large body of evidence strongly suggests that ischemia reperfusion injury is an inflammatory disease mediated by both adaptive and innate immune systems. Cell migration also plays an important role in embryonic development and inflammation, and this process is highly regulated to ensure tissue homeostasis. One such paradigm exists in the developing nervous system, where neuronal migration is mediated by a balance between chemoattractive and chemorepulsive signals. The ability of the guidance molecule netrin-1 to repulse or abolish attraction of neuronal cells expressing the UNC5B receptor makes it an attractive candidate for the regulation of inflammatory cell migration. Recent identification of netrin-1 as regulators of immune cell migration has led to a large number of studies looking into how netrin-1 controls inflammation and inflammatory cell migration. This review will focus on recent advances in understanding netrin-1 mediated regulation of inflammation during acute and chronic kidney disease and whether netrin-1 and its receptor activation can be used to treat acute and chronic kidney disease.