Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease

Figure 4

Netrin-1 regulates neutrophil and monocyte mediated inflammation through suppression of COX-2 expression and PGE2 production. Netrin-1 acting through UNC5B receptor induces the activation of PPARγ. Activation of PPARγ and other signaling pathways like PI3K causes suppression of IκB degradation and inactivation of NFκB transcription factor. NFκB activation is required for COX-2 induction. In the absence of NFκB activation COX-2 expression and PGE2 production was suppressed. This leads to reduced IL-17 production and IFNγ production thereby suppresses inflammation and tissue injury during ischemia reperfusion injury.